THE REGULATION OF SKELETAL MUSCLE FUNCTION BY MUSCLE GP130 SIGNALING
نویسندگان
چکیده
منابع مشابه
Does regulation of skeletal muscle function involve circulating microRNAs?
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Recently, growing evidence has shown that miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by other cells. Circulating levels of several miRNAs are changed in diseases such as cancer, diabetes, and cardiovascular diseases; therefore, they are suggested to regulate...
متن کاملThe molecular regulation of skeletal muscle mass
1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occurs more rapidly than synthesis and is observed in numerous conditions includin...
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The interaction between highly purified rabbit muscle phosphorylase kinase and CaZf has been investigated and this metal has been shown to be necessary for enzyme activity. Utilizing caldum-free reagents, apparent Km values for Ca2f were determined for the activated kinase (2 x 10’ M at pH 8.2, 5 x 10e7 M at pH 6.8) and for the nonactivated kinase (3 X lob6 M at pH 8.2, indeterminate at pH 6.8)...
متن کاملComparison of the Alterations of Gene Expression Related to Signaling Pathways of Synthesis and Degradation of Skeletal Muscle Protein Induced by Two Exercise Training Protocols
Background and Objectives: Skeletal muscle mass depends on the balance between synthesis and degradation of muscle protein, which changes with aging and disease. The aim of the present reserch was to examine the effects of two exercise training protocols on alterations of some genes involved in pathways of protein synthesis and degradation in order to achieve a more effective training program i...
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Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 (PARL ortholog) maintains the function and lifecycle of mitochondria. We examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin resistance. PARL mRNA and mitochondrial m...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2018.32.1_supplement.852.1